NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo

The NBCe1 Na+-HCO3- cotransporter and NHE1 Na+/H+ exchanger both mediate Na+-loading and intracellular pH regulation in cardiomyocytes. Inhibition of NHE1 protects against ischemia-reperfusion (IR) injury, and evidence suggests that loss of NBCe1 activity could also be cardioprotective. We have developed a conditional NBCe1 knockout mouse model and have used it to determine the effects of NBCe1 ablation in cardiac muscle. These studies demonstrate that loss of NBCe1 does not impair cardiac performance. However, cardiomyocyte apoptosis following IR injury in vivo is much lower in hearts that lack NBCe1, thus indicating that loss of NBCe1 is cardioprotective.

Antegrade femoral artery puncture

To determine the optimal site for antegrade puncture of the femoral artery, the authors evaluated three
cadaver specimens and computed tomographic (CT) scans of 50 patients.The relationships among the
common femoral artery, the femoral artery bifurcation, the center of the femoral head, and the inguinal ligament were evaluated. CT showed that the center of the femoral head was always located caudal to the level of the inguinal ligament but cranial to the bifurcation of the common femoral artery. Therefore,the femoral head seems to provide a reliable landmark for entering the
common femoral artery.

How to write a research protocol

How to write a research protocol

resistant hypertension

 The European Society of Cardiology (ESC) guidelines defined resistant hypertension as the failure to achieve BP ‘control’ to levels below 140/90mm Hg despite treatment with three antihypertensive medications with complementary mechanisms of action (with at least one diuretic).


 The American Heart Association (AHA) guidelines adopted an extended definition to also include patients with four or more antihypertensive medications, even when BP was controlled.

the physiological effects of PCI on stable single vessel coronary artery disease

https://t.co/mriyWOinLz

CHA2DS2-VASc

CHA2DS2-VASc (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes, Stroke/transient ischemic attack, Vascular disease, Age 65 to 74 years, Sex category) score by comparing the score at 2 or more different time points in patients with atrial fibrillation (AF) is an indication of OAC

Imaging before cardiac resynchronisation therapy implantation—luxury or necessity?

Lessons Learned From the Discontinuation of a Disappearing Stent

Lessons Learned From the Discontinuation of a Disappearing Stent

What Happens in Each Clinical Trial Phase

What Happens in Each Clinical Trial Phase

RETROGRADE POPLITEAL ARTERY ACCESS FOR ANGIOPLASTY OF CHRONIC TOTAL OCCLUSION OF THE ILIOFEMORAL ARTERY

RETROGRADE POPLITEAL ARTERY ACCESS FOR ANGIOPLASTY OF CHRONIC TOTAL OCCLUSION OF THE ILIOFEMORAL ARTERY

Top 1% of the peer review in the world

Top 1% of the peer review in the world 

Palliating Premature Infants With Obstructed Total Anomalous Pulmonary Venous Connection via Catheterization

Palliating Premature Infants With Obstructed Total Anomalous Pulmonary Venous Connection via Catheterization

Ankle brachial index

UTILIZATION OF POPLITEAL ARTERY ACCESS FOR OCCLUDED ARTERIES

First DM Cardiology student Dr Dibyasundar at AIIMS Bhubaneswar

Clinical role of serum Copeptin in acute coronary syndrome

In conclusion, our study revealed that Copeptin concentration is significantly higher in patients with AMI compared to patients with UA. Moreover, Copeptin rises at a time when other biomarkers namely the routinely used markers; cTns and CKMB are still undetectable